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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and participants from different geographical regions. This kind of heterogeneity is required for pragmatic trials to be able to prove their validity, and it also reduces the chance of bias in the results. However too much heterogeneity could cause issues with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically ordered by policymakers and practitioners to guide their decisions. They can be used to determine the causality of an intervention and its results. However, they shouldn't be used to substitute for explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace tests for explanations or if they should be an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which confirm the validity of a physiological or clinical hypothesis, and pragmatic trials, 프라그마틱 슬롯 사이트 슬롯체험 (Socialmarkz.Com) that inform policy and practice decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the traits of a practical study which includes recruitment, design, implementation of the intervention and its follow-up.

There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This is an indication that the health sciences community is becoming more sensitive to the issue of pragmatics. It is important to remember, 프라그마틱 무료체험 however, that the majority were conducted in primary-care settings.